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Autologous Adipose Stem Cell Therapy

Offered at Hawaii Center for Regenerative Medicine

The medical field is a buzz with promising reports and research on stem cell therapy. Stem cells have the potential to regenerate into any type of body tissue. Liza Maniquis-Smigel, MD, founder of Hawaii Center for Regenerative Medicine, uses stem cell therapy in the treatment of musculoskeletal injuries and disorders. This includes treatment of knees, shoulders, spine and more.

Autologous adipose stem cell therapy uses a person’s own healing cells from fat and blood (alone or in various combinations). They are injected into the area that has a cellular deficiency to stimulate cell regeneration and repair. The advantages of adipose stem cell therapy (compared to other sources of regenerative cells) are that adipose cells yield more stem cells than other sources and patients receive their own cells, so there is no risk of immune rejection. The procedure is also minimally invasive with little to no downtime.

Dr. Smigel has found that stem cell therapy is greatly enhanced when used in conjunction with Platelet Rich Plasma (PRP) therapy for certain types of injuries. PRP contains several substances that stimulate healing including:

  • Platelet-Derived Growth Factor which attracts immune system cells to the area and stimulates them to proliferate. This is particularly helpful in ligament and tendon healing.
  • Transforming Growth Factor-8 which is secreted by all major cell types involved in healing.
  • Vascular Endothelial Growth Factor helps new blood vessel formation, thereby increasing vascularity in injured areas.
  • Fibroblast Growth Factor promotes the growth of the cells involved in collagen and cartilage formation.

The total procedure time is approximately two hours. The following outlines the basic sequence of events:

  • Harvest: 100-200cc of adipose tissue is harvested from the patient using a liposuction procedure.
  • Separate: Adult stem cells are separated from the fat cells using advanced protocols.
  • Activate: The isolated adult stem cells are added in the person’s own platelet rich plasma
  • Administer: The activated stem cells are administered directly into injured structures.

Dr. Smigel’s goal with all forms of therapy is to get the patients back to doing the things they want to do without pain. Anyone interested in learning more can schedule a consultation with Dr. Smigel.

Locations: 928 Nuuanu Ave. #210, Honolulu, and 136A Uluani St, Hilo. For more information, call 808-933-3444 or visit ProloHawaii.com.




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